4-[1-(ethoxycarbonyloxy)ethoxy]-2-methyl-n-(2-pyridyl)-2h-1,2-benzothiazine-3-carboxamide-1,1-dioxide

Name	Ampiroxicam
Synonyms	Nasil Flucam CP 65703 AMPIROXICAM Ampiroxicam 2H-1,2-Benzothiazine, carbonic acid deriv. 4-[1-(ethoxycarbonyloxy)ethoxy]-2-methyl-n-(2-pyridyl)-2h-1,2-benzothiazine-3-carboxamide-1,1-dioxide Carbonic acid, ethyl 1-[[2-methyl-1,1-dioxido-3-[(2-pyridinylamino)carbonyl]-2H-1,2-benzothiazin-4-yl]oxy]ethyl ester Carbonic acid, ethyl 1-[[2-methyl-3-[(2-pyridinylamino)carbonyl]-2H-1,2-benzothiazin-4-yl]oxy]ethyl ester, S,S-dioxide
CAS	99464-64-9
EINECS	807-877-6

Molecular Formula	C20H21N3O7S
Molar Mass	447.46
Density	1.44±0.1 g/cm3(Predicted)
Melting Point	159-161?C
Water Solubility	Chloroform (Slightly), Methanol (Slightly)
Solubility	DMSO 90 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
Appearance	Form Solid color White to Off-White
pKa	12.74±0.20(Predicted)
Storage Condition	Sealed in dry,2-8°C
Use	Ampixicam is a new type of long-acting xixicam non-steroidal anti-inflammatory drug jointly developed by Pfizer Pharmaceuticals and Toyama Chemical Co., Ltd. of Japan. It is a prodrug of piroxicam and is hydrolyzed by enzymes after oral administration. It shows activity and is a cyclooxygenase inhibitor. This product has the remarkable characteristics of strong effect, long duration, high safety, good gastrointestinal tolerance, etc., and has attracted much attention in the pharmaceutical market. Animal experiments show that this product has the same analgesic and anti-inflammatory effects as piroxicam, and the inducing effect of gastric mucosal damage is far weaker than piroxicam. Clinically, this product 27mg has approximately the same bioavailability as piroxicam 20mg.

Toxicity

LD50 orally in male, female rats: 1798, 747 mg/kg (Iijima)

Raw Materials

Ampiroxicam is a non-selective cyclooxygenase (cyclooxygenase) inhibitor as an anti-inflammatory drug.

Last Update：2022-10-16 17:30:58

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CAS: 99464-64-9
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Mobile: 18021002903
QQ: 3008007409

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Raw Materials for 4-[1-(ethoxycarbonyloxy)ethoxy]-2-methyl-n-(2-pyridyl)-2h-1,2-benzothiazine-3-carboxamide-1,1-dioxide

Potassium
Piroxicam

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